Course Description
ΥΠB8 - Algorithms in Structural Bioinformatics
Code: ΥΠΒ8
Title Course: Algorithms in Structural Bioinformatics
Semester: 2nd
Category: REQUIRED (Bioinformatics)
Lecture hours: 3
Instructor: Emiris (NKUA)
Course web page: http://eclass.uoa.gr/courses/D464/
Course Description:
Introduction to structural biology; primary, secondary and tertiary structure. Dynamic programming and complexity; sequences and alignment, alignment with gaps. Structure comparison and alignment. Databases of biological information (e.g. Protein Data Bank), experimental data from Nuclear Magnetic Resonance and X-ray crystallography. Study and computation of 3D structure, conformational search. Distance geometry, triangular and tetrangle inequality, distance matrix. Molecule kinematics and rigid transformations; degrees of freedom. Solving of polynomial systems via linear algebra. Molecular surface modeling and flexibility; Delaunay triangulation, alpha-shapes. Applications to protein docking. Geometric data structures and geometric hashing. [Previous page]
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National and Kapodistrian University of Athens Department of Informatics and Telecommunications