Garbis Spyros
Investigator (Lecturer Level)
Instit.: BRFAA
Tel: (+30) 210-6597131
Personal Web Page: http://www.bioacademy.gr/Faculty/investigators_details_new.php?id=10&inv=0&ovr=0
Short Bio:
Dr. Spiros D. Garbis received his BSc degree in Chemistry from the University of Illinois in 1989. As a research chemist he worked at Honeywell Zellweger Analytics in the area of environmental toxicology using remote sensing molecular spectroscopy technologies from 1990-1995. He later worked as a forensic scientist at the Animal Forensic Toxicology Laboratory of the University of Illinois, Department of Biopharmaceutical Sciences from 1994 - 1998 where he developed and applied methodologies based on bioanalytical mass spectrometry (MS) techniques in the determination of xenobiotic substances and their metabolites in biological fluids and tissues. His exposure in the area analytical toxicology prompted him to pursue doctoral training under the mentorship of Prof. Dr. Richard B. van Breemen at the University of Illinois, Department of Medicinal Chemistry and Pharmacognosy from 1998 - 2003 where he received his PhD in 2003 in the area of Molecular and Biochemical Toxicology.
His dissertation involved the use of MS based proteomic and metabonomic approaches to the study of the bioavailability, biotransformation and bioequivalence properties of folate species in humans. As a tenure track research chemist at the Biomedical Research Foundation of the Academy of Athens (BRFAA), Center for Basic Research, Biotechnology Division.
Dr. Spiros D. Garbis is involved in the development and application of novel liquid chromatography - tandem mass spectrometry (LC-MS) techniques in the characterization of peptides and proteins in biological samples. In order to accurately address complex biological processes, he is currently involved in the method development of multi-dimensional LC-MS platforms. As such, he has established in-house capabilities for the preparation of custom capillary columns utilizing advanced chromatographic chemistries to be used in combination with various MS architectures including nano-electrospray-quadrupole time-of-flight, ion trap and matrix assisted laser desorption tandem time-of-flight instrumentation. In addition, he is currently involved in the design and application of integrated lab-on-a-chip devices in collaboration with Democritos. Such devices hold promise in increasing analysis throughput and sensitivity for the MS based determination of low abundance biomolecules in complex biological matrices.

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